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Heterozygous and KO mice were co-housed except during food intake measurements and calorie restriction experiments

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A detailed description of the potential pathways leading to steatohepatitis exceeds the scope of this review, therefore we refer the reader to recent in-depth reviews involving a broad spectrum of mechanisms involved in the development of NASH and liver fibrosis (11,69-72)

Gene therapy as a curative option for Beta-thalassemia

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VX-150 also has a significant effect on cold pressure pain thresholds and heat pain thresholds