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In NSCLC cells with sensitive EGFR mutations, EGFR kinase inhibitors can trigger autophagy by disrupting tyrosine phosphorylation of Beclin-1, leading to enhanced tumor growth and resistance to TKI treatment (273)

In the Abatacept inhibits inflammation and onset of rheumatoid arthritis in individuals at high risk or ARIAA trial, abatacept treatment for six months among RA-at-risk individuals (anti-CCP positive and showing MRI signs of inflammation) reduced subclinical joint inflammation and delays the development of RA (62)

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