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Therefore, to demonstrate whether adipocytes can undergo apoptosis in response to oxidative stress, one study treated mature adipocytes with H 2 O 2 and found that an increase in ROS enhanced adipocyte apoptosis (80)

Imidazole ketone Erastin (IKE) achieves markedly greater potency and stability through an imidazole ketone scaffold that enables durable target engagement while resisting metabolic clearance (76)

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showed that withaferin A directly suppresses IKK kinase activity, which phosphorylates IB prior to its ubiquitination and destruction [116]