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GLP-1 patients typically notice appetite reduction within 12 weeks and measurable weight loss by weeks 48

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Warnings and Precautions 5.1 Neutropenia Neutropenia was the most frequently reported adverse reaction in PALOMA-2 with an incidence of 80% and PALOMA-3 with an incidence of 83%

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Testosterone levels typically decline by about 1% per year after age 30