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doi:10.1136/gut.2004.060103 19Lim W-C, Wang Y, MacDonald JK, et al

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Conversely, IGF-1 acts to provide an inhibitory feedback signal on GH secretion in the hypothalamus by stimulating somatostatin production in the pituitary [8991]

Early clinical data from Palatin indicated that bremelanotide on its own, and even more so combined with a PDE5i, produced statistically significant improvements in erectile function in men