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Preclinical research has shown that L-methionine supplementation can directly activate the hepatic SIRT1/AMPK signaling pathways, which are crucial for regulating cellular energy homeostasis and improving circulating lipid profiles

[DOI] [PubMed] [Google Scholar] 519.Clancy H, et al

Evidence-Based Complementary and Alternative Medicine 2011(1):531053 Jedlika M, Feglarov T, Janstov L, Hortov-Kohoutkov M, Fri J (2022) Lactate from the tumor microenvironment-a key obstacle in NK cell-based immunotherapies