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2.4.3 Signaling pathway alterations Beyond activating inflammatory and cell death cascades, overwhelming oxidative stress pathologically alters numerous other intracellular signaling pathways crucial for myocardial function and survival

The other cytokines testedIL-4, TNF-, and INF-did not show any significant changes, probably due to the short study period

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253,254 Therefore, chemical modification at this specific position could improve siRNA binding affinity

10.3389/fphar.2015.00323 4

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