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Shindell et al., 2020) (Executive Summary Fig

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10.1016/j.pneurobio.2010.08.001 162 WangN.ZengG.-Z.YinJ.-L.BianZ.-X

Some of the common reasons that trigger melanocytes to produce more melanin are: Genetics Hormonal changes Sun exposure Thyroid disease Medications Infrared radiation Pregnancy Skincare products Sometimes melasma appears during pregnancy and disappears once the baby is born but in some cases, it lingers

This medication may interact with gonadotropin-releasing hormone agonists/antagonists (such as Leuprolide and Cetrorelix), androgens (including testosterone), and anti-androgens (such as Flutamide)