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The cytokines and oxidative stress byproducts arising from synovitis further activate synovial cells and chondrocytes to release additional inflammatory mediators and catabolic enzymes

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Lange, A., Lange, J

Cephaeline promotes ferroptosis by targeting NRF2 to exert anti-lung cancer efficacy

These reactions are typically temporary and subside within a few hours

Electrons are then transferred from the oxidoreductase flavoenzyme to the appropriate electron carrier, either oxidized thioredoxin (Trx-S2) or glutathione disulfide (GSSG) converting them to reduced thioredoxin (Trx-[SH]2) or glutathione (GSH), respectively