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10.1016/j.tips.2016.12.004 93 RussoE

This limitation makes conventional vitamin C a poor candidate for therapeutic conditions that demand high absorption vitamin C for sustained or elevated plasma concentrations, such as immune modulation, oxidative stress recovery, and surgical healing

PloS One 9 (2), e86075

(PubMed) He K, Liu K, Daviglus ML, et al

This results in cleaved glutamate, cysteine and glycine while facilitating the transfer of -glutamyl moiety of GSH to either water (hydrolysis) or substrates such as peptides (transpeptidation)

In these genetically susceptible individuals, the toxins recirculate indefinitely, causing chronic, systemic inflammation