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Meanwhile, TMAO can significantly upregulate the expression level of PIEZO1 and enhance the sensitivity of chondrocytes to mechanical loading, and this effect may be closely related to the pathogenesis of OA (Zhuang et al., 2023)

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3.10 Catabolic processes were further suppressed in acute CHL compared to chronic CHL We identified 8 upregulated and 95 downregulated proteins in acute CHL ( n = 14) compared to chronic CHL ( n = 17) (Supplementary Figure S6A