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APE1 was also one of the many non-regulatory proteins involved in cancer survival signaling pathways, and could be used as a therapeutic target in the treatment of multiple types of tumor cells [24]

Combination trials incorporating epigenetic modulators are rapidly expanding across solid tumors, reflecting growing recognition that non-genetic resistance is a critical bottleneck to durable response (205)

However, large-scale, randomized controlled trials (RCTs) remain scarce, limiting their clinical translation

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But over 12 weeks of consistent use with proper diet and training, the fat loss is significant and sustainable