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Conversely, homozygous TASTPM AD mice (bearing mutations in APP KM670/671NL and PSEN1 M146V) and P301L Tau mice initially exhibit low Igfbp2 expression in the cerebral cortex during early stages but show significant increases in later stages [148]

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Results in one strain may not reproduce in another

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Notably, baseline levels of butyrate and butyrate-producing species positively correlate with clinical response to antiTNF- therapy in humans (201, 202), highlighting butyrate's role in restoring epithelial barrier function, immune regulation, and biologic therapy efficacy