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This results in endoplasmic reticulum stress, lipid peroxidation, and ferroptosis, subsequently reducing TNF- and IFN- production and increasing PD-1 expression [139]

Development of a 3D angiogenesis model to study tumour endothelial cell interactions and the effects of anti-angiogenic drugs

Cancer Lett 371:1219 Dos Santos SM, Romeiro CFR, Rodrigues CA, Cerqueira ARL, Monteiro MC (2019) Mitochondrial dysfunction and alpha-lipoic acid: beneficial or harmful in Alzheimers disease

Disulfidptosis: a new form of regulated cell death for cancer treatment

This section will then further specify how the active TGF- isoform functions alone or with the cross-talk of other environmental cues, balances the self-renewal of stem cells, assists with differentiation during normal physiological development, and how TGF- acts as a pro-migratory factor to mobilize adult stem cells from their unique niche to repair damage and maintain normal tissue homeostasis

10.1016/j.plaphy.2020.11.047 36