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Labwork at that time was notable for an elevated uric acid of 10.6mg/dl (reference range: 3.5 - 8.5 mg/dl.) Out of concern for TLS precipitating hyperuricemia in the setting of a high-grade tumor in addition to starting a new chemotherapy regimen, the patient was additionally given 10mg of rasburicase and started on 300mg of allopurinol daily

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Amgen has begun recruiting for its next phase 2 trial with AMG-133, which will aim to understand AMG-133's efficacy in more patients over a longer period of time 2

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For 10unit (0.10 mL) administrations during titration, consider 30 or 50unit insulin syringes for improved readability

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