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it is represented by 0.037%

(Note: gabapentin alone accounted for ~1.6% of all prescriptions in 2025)

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For instance, in the metabolism of aromatic amines such as 2-naphthylamine and 4-aminobiphenyl, the CYP450 enzyme familyparticularly CYP1A2catalyzes N-hydroxylation, producing N-hydroxy aromatic amines