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LKB1 activates AMPK and AMPK-related kinases, leading to the upregulation of catabolic pathways and mitochondrial biogenesis, while simultaneously suppressing anabolic processes to maintain this metabolic resting state[15, 46]

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By engineering an antigen-specific single-chain variable-fragment antibody (scFv) fused to intracellular lymphocyte signaling domains, T cells are functionally redirected to specific surface molecules on tumor cells

One tumor-enhancing characteristic found in CAFs is the reverse Warburg effect [65, 66]

Because the genetic code is redundant, a substitution does not always change the amino acid sequence

To evaluate whether the drug itself might interfere with the GST-CDNB spectrophotometric assay at 343 nm, and determine the limits of inhibitor concentrations to be used for the assay, absorbance measurements were performed with the various dilutions of the stock solution of Atazanavir