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In male reproductive pathology, ROS generated by mitochondria in asthenozoospermic sperm cause nuclear DNA strand breaks [358] and compromise chromatin condensation integrity through aberrant histone methylation patterns, which directly correlates with diminished sperm quality [351]

These included TCA cycle intermediates such as citrate, cis -aconitate, -ketoglutarate, and various amino acids including glutamate, proline, aspartate, asparagine, and alanine as well as glutathione, pyroglutamate, and ornithine

Front Neuroanat (2015) 9:91.10.3389/fnana.2015.00091 6 BoscoDAFowlerDMZhangQNievaJPowersETWentworthPet alElevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization

Reference Sappl, Carroll, Clifton, Lister, Whelan, Millar and Singh2009

Cellular responses to oxidative stress: Adaptation, damage, repair, senescence and death

Pyrgiotakis, G