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10.1002/bmc.174 Biomed

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Vascular permeability in ocular disease and the role of tight junctions

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Increased GSTP1 expression in tumours and in drug-resistant cells is also the target of a new class of GST suicide inhibitors, including 7-nitro-2,1,3-benzoxadiazole (NBDHEX) (Ricci et al, 2005), which acts to induce apoptosis by promoting dissociation of the GSTP1/JNK1 complex in leukaemia cell lines (Turella et al, 2005)