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Further research is needed to elucidate the specific mechanisms underlying these effects

Notably, OGD did not significantly change V max within the 7KR group (Figure 6D and 6F), and K m values were unchanged across all conditions (4h: F (3,12) = 0.5862, p = 0.6355

While the experimental models employed in PD have shown connections to human health, it remains a daunting task to translate mechanisms of action observed in in vitro and in vivo studies of natural compounds to clinical outcomes in human trials, where it is a critical step in drug development

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PLoS ONE 9 , e95499 (2014)