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Clinically, iron levels in the substantia nigra are significantly higher in PD patients compared to controls (61)

doi: 10.1155/2015/263109 404 HaegerMBengtsonAKarlssonKHeidemanM

All TARDBP family fibroblasts, apart from the late-stage patient fibroblasts, had a higher expression level of OPA1 than unrelated controls, while MFF content was slightly higher only in TDP-43 G376D Asymptomatic and late-stage patient fibroblasts compared to both unrelated and familial CTRLs (Fig

solvent not reported) is capable of enhancing mitochondrial activity while acting against oxidative stress and improving mitochondrial membrane potential (Bej et al., 2024b)

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Role of Oxidative Damage in Alzheimers Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery