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Mason 2020)

Current pharmacotherapy of heart failure with reduced ejection fraction (HFrEF) includes combination therapy with angiotensin-converting enzyme inhibitors (ACEi) and -adrenergic receptor blockers (-AR blockers), a therapy also used as treatment for non-cardiac conditions

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Adult is not indicated for use in pediatric patients below the age of 11 years

Overall, respiratory chain activity plays a key role in supporting amino acid homeostasis and cell proliferation, although the specific mechanisms vary among different organisms studied to date

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