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Funding This study was supported by the Guangdong Medical Science and Technology Research Foundation (A2022479), the Guangdong Basic and Applied Basic Research Foundation (2023A1515011699), the University-Hospital Joint Fund Project of Guangzhou University of Chinese Medicine (GZYZS2024U08), and the Scientific Research Project of Guangdong Provincial Administration of Traditional Chinese Medicine(20251432)

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For example, boosting NAD + through NR administration could confer anti-inflammatory effects on tissue macrophages, in which NR supplementation attenuated the type I IFN signaling pathway, an important myeloid regulatory program, through the increased inosine level and the subsequent suppression of autophagy [97]

(2023) Loss of neuron navigator 2 impairs brain and cerebellar development

However, these changes were reversed following treatment of animals with L-carnitine alone

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