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10.1016/j.stem.2010.11.028 62 LeemanD

Each batch undergoes over 230 quality checks to ensure it is free from heavy metals, contaminants, and toxins

Bioresponsive polyplexes-chemically programmed for nucleic acid delivery

To clearly illustrate the experimental basis for these findings, Table 1 summarizes key studies supporting the core pathways, including the experimental models used, the CKD stage or modeling approach, and the significant findings

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These quinolines are characterized by a weak basic moiety and a lipophilic chain in the quinoline structure, and the leishmanicidal response has shown a consistent correlation with depolarization of mitochondrial potential, promoting a series of biological and biochemical consequences into the parasite, including an increase of ROS production, alteration of parasite morphology and parasite death via apoptosis (Figure 6)