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Study design and participants The REDEFINE-1 trial is a large phase 3 study testing treatments for obesity

GLP-1 therapy is no longer injection-only

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In 2021, a new era in obesity pharmacotherapy was established with the FDA approval of semaglutide, a high-dose glucagon-like-peptide-1 receptor (GLP-1R) agonist which causes about a 12% placebo-subtracted weight loss in people with obesity at 68 weeks of treatment (5)