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Because ferroptosis is a fundamental metabolic process, its systemic modulation may inadvertently affect non-target tissues, particularly for broadly acting agents such as iron chelators or GPX4 inhibitors

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14 NAD + biosynthesis De novo pathway Mammalian cells can generate NAD + de novo from dietary tryptophan (Trp) by the kynurenine pathway (KP), which is initialized by either TDO or IDO

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