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Three subjects were excluded from all AUC 024h and C max Day 10 analyses: two withdrew from the trial before the 10th dose (one subject in each of the 2 hnight and night30 min treatment arms as described above) and one subject had an incomplete Day 10 pharmacokinetic profile (6 h30 min treatment arm)

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doi: 10.1111/cen.12185 23 KimTHKoJKimBRShinDYLeeEJYoonJS

Supplemental Tables S3&S4 ), as expected 2

10.1111/j.1460-9568.1992.tb00177.x 117

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