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These changes not only resulted in a substantial decrease in mitochondrial activity, but were also coupled with a reduction in the expression of MFN2 and OPA1, exacerbating impaired mitochondrial fusion and increasing mitochondrial fragmentation ( 5.3 Mitochondrial biogenesis and COPD Mitochondrial biogenesis is crucial for maintaining cellular homeostasis and it enables cells to replace damaged or aged mitochondria with new ones, thus maintaining normal morphology, structure, and function of mitochondria

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TMAO was shown as widely distributed in sea animals [74], with concentration in the tissue increasing proportionally to the depth of the fishes natural environment [75]