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At equimolar doses, this novel compound, GIC-1001 (trimebutine 3-thiocarbamoylbenzene-sulphonate), shows rapid onset of action (2 h) and more effectively mitigates nociceptive responses to colorectal distension, providing pain relief during colonoscopy (Table 4)

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Patients should be offered genetic testing if they have a personal or family history of intrahepatic cholestasis, such as PFIC, BRIC, ICP, and LPAC combined with drug at-cholestasis risk use [20] (Fig

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