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It should be noted that anthraquinones are excreted mainly with the urine, bile or feces in the form of its prototype or metabolites

Additionally, a 1-year randomized Phase II clinical trial in patients with atrophic macular degeneration showed a favorable safety profile and benefits for vision maintenance (184)

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demonstrated that administration of oral L-arginine induced radiosensitization and local control in patients who underwent standard radiation therapy [112], which is associated with increased DNA damage via nitric oxide (NO)-mediated metabolic suppression [112]