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In the context of CKD, iron deposition is accompanied by the increased expression of iron input proteins (ZRT/IRT-like proteins, ZIP14 and ZIP8) or the decrease in FPN1 expression, indicating that iron accumulation may be triggered by increased iron uptake or insufficient iron efflux (Fig

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Ferroptocide (FPT) is an active small molecule natural product modifier capable of inducing ferroptosis by covalently modifying the active site of thioredoxin (TNX), thereby interfering with the cellular antioxidant system and altering lipid peroxidation and redox status

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306 In fact, tumor-induced thromboembolism is the second most frequent cause of death in cancer patients

and Ig domain-containing MHC homologs such as MICA and RAE-I (Wouters et al., 2007)