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1c), and we noted a significant increase in T-cell death (Fig

This may occur upon discontinuation of treatment

Cardiovascular disease: Due to the cardio stimulatory effects of thyroid hormones, care should be exercised when initiating thyroid replacement therapy in individuals with cardiac diseases such as angina, arrhythmias, or a previous myocardial infarction

Due to different mutations, patients with variants in the same gene may display a variety of phenotypes (allelic heterogeneity) [82]

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