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This research was supported by CSIR [MLP137-MISSION LUNG] and DST-SERB [GAP-432]

479 Mitochondrial dysfunction disturbs T-cell homeostasis by activating cell death pathways involving Bcl2, OPA1, PHB2, ATG5, OMA1, and SIRT3, while reduced OXPHOS, membrane potential instability, and altered glycolysis further destabilize immune function

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Prolonged, excessively high-dose supplementation (daily intake exceeding 50,000 IU) may lead to toxicity, causing hypercalcemia, hypercalciuria, and associated symptoms such as nausea, vomiting, kidney stones, and ectopic calcification of soft tissues (50)

The expression of MMPs in human skin is increased by ultraviolet radiation