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BMJ article on ethical approval from 2009 bmj.com/content/338/bmj.b450 The letter just says in line with guidelines

The influence of ACPA status and characteristics on the course of RA

However, in dorsal root ganglion neurons obtained from arrestin 3 KO mice, acute MOR desensitization elicited by DAMGO or morphine on the inhibition of voltage-gated calcium channels was not significantly different from wild type mice indicating that arrestin 3 has no major role in those conditions (Walwyn et al., 2007)

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299 Additionally, molecular studies on genetic predispositions offer insights into personalized preventive strategies

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