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Additional at-risk groups include: Vegans and strict vegetarians , who may have low dietary B12 intake People with autoimmune conditions , including pernicious anaemia or type 1 diabetes Individuals with gastrointestinal conditions such as Crohn's disease or coeliac disease, which impair nutrient absorption People who have undergone bariatric surgery , which can significantly reduce B12 absorption Long-term users of proton pump inhibitors (PPIs) or H2-receptor antagonists , which reduce gastric acid and impair B12 release from food Those with a family history of either pernicious anaemia or diabetes For these groups, simultaneous monitoring of B12 status and glycaemic markers is particularly important to avoid diagnostic errors

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Alcohol impairs fat metabolism, disrupts sleep quality, adds empty calories, and can stress the liver

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More recent literature has revisited the fragment in the context of combination studies, where researchers pair it with secretagogues to separate direct adipose effects from endogenous GH-axis activation

AOD9604 The Clinical Development Derivative A stabilised, modified form of HGH Fragment designated AOD9604 was advanced into clinical development for obesity research