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Multiple tumor suppressors that repress PI3K/AKT/mTOR and HIF-1 signaling are epigenetically silenced by promoter hypermethylation, including PTEN 126, 127, 128, 129, 130 , LKB1, 131, 132 VHL 133, 134, 135, 136 and prolyl hydroxylases (PHD1/2/3)

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Results showed a steady increase in glutathione levels when compared to the baseline

Rahman, I., et al., Characterisation of gamma-glutamylcysteine synthetase-heavy subunit promoter: a critical role for AP-1

S-containing compounds play pivotal roles in the metabolic process by working as redox substances, coenzymes, and signaling molecules