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It primarily infects small rodents but can also infect humans which are dead-end hosts

10.1038/nchem.2133

When NNMT depletes SAM in adipocytes, epigenetic regulation is disrupted potentially locking in gene expression patterns that favor energy storage over expenditure

This disease occurs in about 820 per 100,000 people, affecting approximately 2754 million people worldwide ( Studies have found that the best predictor for islet autoimmunity is genetic background, with predisposition caused by genetic susceptibility in multiple loci, including INS and the class I and II Major Histocompatibility Complex (MHC)/human leukocyte antigen (HLA) genes ( Figure 1 ) ( Figure 1 )