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Not because the solution becomes unsafe, but because it becomes ineffective

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Depending on the depth of an aquifer, the size of the spaces in the soil or rock, and how well the spaces are connected, groundwater can creep along as slowly as a few centimeters a century, or move as fast as several feet a day

Sodium valproate is associated with increasing ammonia levels and decreasing carnitine status, and carnitine intervention has been found to normalise both

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