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Many studies indicate that a mutual relationship exists between spine morphology and function of synapses 1,4 , and that the actin cytoskeleton has a critical role in modulating the efficacy of their pre- and postsynaptic terminals 2,5

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Phase 1b: Multiple Ascending Dose Study (NCT03014609) Study Title: "Safety, Tolerability, PK and PD of Multiple Doses of Cagrilintide in Subjects With Type 2 Diabetes" Status: Completed Phase: Phase 1b Enrollment: 56 participants with T2D Study Period: 2017-2018 Design: Randomized, double-blind, placebo-controlled Duration: 12 weeks Dose Range: 0.3-4.5 mg SC weekly Population: T2D, BMI 25-40, HbA1c 7-10% Key Results: Weight Loss: 6.0 kg (4.5 mg dose) vs

Units: Markings shown on many U-100 syringe barrels