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The hypothesis behind the LMR is that the smaller mannitol (6.7 ) can pass via the pore pathway and can be considered as a marker for the total small intestinal surface, while the larger disaccharide lactulose (9.5 ) will only pass the larger pores of the leak pathway in the crypt region and at sites where the barrier is damaged (13)

doi:10.1007/s12015-020-09969-6

Plos One 15 (3), e0230374

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