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Considering the heterogeneity of populations resulting from dietary, geographic, and genetic differences, as well as from distinct microbiota composition, is crucial to understanding the relationship between selenium and the gut microbiota [5, 126,127,128]

4) and the relationship between precise patient-specific control of activation level and CAR T cell functionality 20 , we hypothesized that rapamycin may have a greater effect on decreasing the activation of STR compared to LTR CAR T cells