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Notably, the disease group known as neurodegeneration with brain iron accumulation (NBIA) refers to neurodegenerative disorders associated with altered iron metabolism in the lesion area and includes Alzheimers disease (AD), 42 Parkinsons disease (PD), 43 and Huntingtons disease (HD)

Among the ebselen derivatives tested, we found compounds with 2-bromophenyl and 2-(3-hydroxypyridin-2-yl) modifications having inhibitory properties towards nsp14 similar to ebselen

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Ion channels such as Piezo1 and TRPV4 respond to mechanical stimuli by altering ion flux across the cell membrane, leading to changes in intracellular signaling pathways

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