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Pathophysiology of Smoking and Liver Disease Prior data has shown that consuming tobacco increases the production of interleukins (IL-1, IL-6), tumor necrosis factor (TNF ), angiogenic agents like vascular endothelial growth factor (VEGF), fibrosis mediators (transforming growth factor ), and angiotensin II

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in 1992, it became that shows highest-rated program, won an Emmy, and made Mirren, according to some television journalists and executives, PBSs pin-up woman of the decade