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However, under the MDD pathological condition, due to the decreased expression of EAATs in astrocytes, excessive glutamate in the synaptic cleft activates synaptic mGluRs, which leads to neuronal excitotoxicity

For example, the TME has a lower pH (ranging from 6.5 to 7.2) compared to that of normal tissues (with a pH around 7.4) owing to the Warburg effect (Liberti and Locasale, 2016), and it is hypoxic due to the insufficient blood supply to tumor tissue and the increased oxygen consumption by cancer cells (Chen Z

48, 519525 10.1016/j.freeradbiomed.2009.11.021 [DOI] [PMC free article] [PubMed] [Google Scholar] Joiner K

Based on scientific evidence (Vyas and Erdman, 2009

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Turmeric has skin-lightening properties to fade dark acne scars from post-inflammatory hyperpigmentation and contains anti-inflammatory properties to reduce scarring