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Ihle NT, Powis G, Kopetz ES

10.1161/CIRCULATIONAHA.110.958033 Circulation 73 HsuehY

These conversions result in the production of glucuronide and sulfate, curcumin compounds that render curcumin more bulky (which further limits curcumin uptake across the gut wall, meaning that a significant proportion of curcumin is excreted unabsorbed in the faeces) and water-soluble (allowing any absorbed curcumin to be easily excreted by the kidneys)

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Uncoupled turnover disrupts mitochondrial quality control in diabetic retinopathy