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Interestingly, we also found that the hypoxia-induced decline in PP2A activity was reversed when -syn or p--syn was interfered with, suggesting that hypoxia-induced PP2A inhibition and -syn pathology are mutually reinforcing vicious cycles

10.1016/0361-9230(86)90233-9 71 KuhneC.PukO.GrawJ.Hrabe De AngelisM.SchutzG.WurstW.et al

Caspases assume a pivotal role in apoptosis, serving as primary executors through the cleavage of cellular proteins, thereby instigating and executing the apoptotic cascade

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The half-life of approximately six days means doubling produces plasma levels significantly higher than intended, increasing side effect risk without proportional benefit

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