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ODD is a research incentiveit provides benefits including extended market exclusivity upon approval, tax credits for clinical trial costs, and expedited reviewnot an evaluation of the compounds safety or efficacy

40(12): 130510 Rebouche CJ, Engel AG

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Wensing KU, Ciarimboli G

Too many of those deficient in Iron and/or B12, are simply given supplements, sometimes indefinitely, to try and raise their levels

3.1 Cellular consequences of macrophage lipotoxicity Excessive intracellular accumulation of FFAs, termed lipotoxicity, can promote pro-inflammatory responses, disrupt cellular homeostasis, induce organelle dysfunction, and ultimately induce cell death in macrophages (69, 70, 80)