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Moreover, the more hydrophobic substrates tyramine and dopamine could be further stabilized by the hydrophobic 2 nd activity controller Leu244, which is supported by the experimental results ( K m values: tyramine = 0.451, dopamine = 0.75 versus tyrosine = 1.42 and L -DOPA = 6.2)

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N -acetylcysteine serves as substrate of 3-mercaptopyruvate sulfurtransferase and stimulates sulfide metabolism in colon cancer cells

(Shanghai, China) and the sequences are listed in Supplementary Table 3