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Zhang HM, Li ZY, Dai ZT, Wang J, Li LW, Zong QB

World J Gastroenterol 15: 4481-4490, 2009

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Measuring thiopurine metabolites in myeloid cells proved to be challenging however it was discovered that thiopurines metabolites are absorbed into red blood cells (RBC) and therefore metabolite measurement using RBC levels provided a practical surrogate for myeloid metabolite levels [55]