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This compound works to selectively inhibit acetylcholinesterase and is antagonistic toward NMDA receptors

239 Treatment with MAT2A inhibitors AG-24152 and AG-270 significantly reduces SAM levels, inhibits PRMT5 activity, and causes DNA damage and mitotic defects in tumor cells

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During the process of brain ageing, the concurrent decline in both the structure and function of these neural cells, along with the presence of comorbidities, results in an imbalance between the stimulation and adaptive responses of the CAS, leading to accumulation of A and tau proteins, neurodegeneration, and ultimately dementia